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The immune response to a chemically induced fibrosarcoma: A comparison of cytolytic T lymphocyte stimulation by transformed and non-transformed fibroblasts by Terry L. Bowlin; Max R. Proffitt is a Immunology and Microbiology article available to read on EtoBox.

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A clone of C3H10T1/2 fibroblasts transformed in vitro with the carcinogen 3-methylcholanthrene readily produced tumors when as few as 103 cells were injected into immunocompetent adult syngeneic mice. A non-transformed clone of the same parentage did not produce tumors. Because the cell-mediated immune response has an important role in inhibiting the growth of tumors, we have compared the ability of both these transformed and non-transformed fibroblasts to stimulate and to act as targets in cell-mediated cytotoxicity (CMC) assays. This model is unique in that studies of the immune response to tumors rarely have or utilize appropriate normal controls. When both types of irradiated fibroblasts were used as stimulators in vitro, neither syngeneic nor allogeneic effector spleen cells capable of efficiently lysing the tumor fibroblasts were generated. In contrast, the normal fibroblasts could both stimulate and be lysed by aUogeneic cytolytic T cells (CTL). However, the tumor fibroblasts could be lysed by allogeneic effector spleen cells that had been sensitized to C3H/He spleen cells. These results suggest that the expression of alloantigenic determinants necessary for stimulating a CM

Who reads The immune response to a chemically induced fibrosarcoma: A comparison of cytolytic T lymphocyte stimulation by transformed and non-transformed fibroblasts?

Author

Terry L. Bowlin; Max R. Proffitt

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0340-7004)

Published

1982

Language

EN

Field

Immunology and Microbiology (Life Sciences)