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Identification of circRNAs and circRNA-miRNA-mRNA regulatory network in radiation-induced heart disease by Shutong Shen; Ping Lyu; Baixia Yang; Xi Yang; Yida Li; Zhengfei Zhu; Li Shen is a Medicine article available to read on EtoBox.

What is Identification of circRNAs and circRNA-miRNA-mRNA regulatory network in radiation-induced heart disease about?

Abstract Objective Radiation-induced heart disease (RIHD) is one of the most common and serious long-term adverse effect after thoracic radiotherapy. Our aim was to investigate the potential molecular mechanism underlying RIHD using RNA-sequencing (RNA-seq) and bioinformatics methods. Materials and methods An RIHD rat model was established and transcription profiles were identified using RNA-seq. Differentially expressed circRNAs, miRNAs and mRNAs were identified. Enrichment of functions and signaling pathways analysis were performed based on GO and the KEGG database. Potential circRNA-miRNA-mRNA regulatory network underlying RIHD was established. qRT-PCR was used to validate the associated genes. Results In total, 21 circRNAs, 26 miRNAs, and 178 mRNA transcripts were differentially expressed in RIHD. GO and KEGG pathway analyses identified that differentially expressed mRNAs were most enriched in pathways referring to endothelial function and vascular pathological processes. Nine circRNAs, 10 miRNAs, and 6 mRNA transcripts were most likely involved in vascular function and a candidate competitive endogenous RNA (ceRNA) network of circRNA-miRNA-mRNA was established, which were furt

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Author

Shutong Shen; Ping Lyu; Baixia Yang; Xi Yang; Yida Li; Zhengfei Zhu; Li Shen

Publisher

Informa UK Limited

Published

2023

Language

EN

Field

Medicine (Health Sciences)