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Omnigenic Model of Polygenic Traits by Abdel Abdellaoui is a document available to read on EtoBox.

What is Omnigenic Model of Polygenic Traits about?

The document discusses the "omnigenic model" which proposes that most genetic variants associated with complex traits exert their effects indirectly through regulatory influences on "core genes". The model suggests that while only a small number of core genes have direct effects on a trait, most genetic variants act through weak effects on distant peripheral genes which secondarily influence core gene expression levels. Though individual peripheral gene effects are small, their combined effects explain most

Author

Abdel Abdellaoui

Language

EN