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Can I read Cytopenias in HIV Infection: Mechanisms and Alleviation of Hematopoietic Inhibition on EtoBox?
Cytopenias in HIV Infection: Mechanisms and Alleviation of Hematopoietic Inhibition by Prasad Koka; Srinivasa Reddy is a Medicine article available to read on EtoBox.
What is Cytopenias in HIV Infection: Mechanisms and Alleviation of Hematopoietic Inhibition about?
Hematopoietic abnormalities including anemia, cytopenias, and alterations of the stem cell plasticity in the bone marrow microenvironment commonly occur in HIV infected patients. These observations suggest that HIV-1 infection may affect processes important during early stages of hematopoiesis or stem cell differentiation. Hematopoietic abnormalities may be caused by altered stem cell differentiation possibly due to abnormal lineage specific expression of certain cellular genes such as cytokines relevant to hematopoiesis. These cytokines could affect regulatory signals important in hematopoiesis. However, in HIV infected individuals, it is not only the virus but also the highly active antiretroviral therapy (HAART) that both contribute to persistent hematopoietic suppression and ensuing cytopenias. Even if a lowering of HIV replication by HAART were to occur in infected individuals, prolonged HAART by itself and/or appearance of drug resistant mutants can contribute to hematopoietic suppression and resulting cytopenias. However, confounding factors such as opportunistic infections, immune mediated effects, or the consequences of prolonged physiological stress, which could contribut
Who reads Cytopenias in HIV Infection: Mechanisms and Alleviation of Hematopoietic Inhibition?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Prasad Koka; Srinivasa Reddy
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)