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Fatigue: a principal contributor to impaired quality of life in ANCA-associated vasculitis by N. Basu; G. T. Jones; N. Fluck; A. G. MacDonald; D. Pang; P. Dospinescu; D. M. Reid; G. J. Macfarlane is a Medicine article available to read on EtoBox.

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Objectives. To describe quality of life (QoL) in an ANCA-associated vasculitis (AAV) cohort and make comparisons with a general population sample. In addition, we aimed to take preliminary steps to identify potential disease and psycho-social factors which may determine QoL impairment. Methods. A population-based case-control study was designed. All AAV patients resident in Grampian, Scotland, were invited to participate as cases. Controls were identified from a random sample of persons registered with four local general practices. Participants completed a questionnaire comprising validated generic and symptom-specific tools in the assessment of QoL. In addition, all cases were clinically assessed and putative disease factors recorded. Cases and controls were compared and, in addition, disease and psycho-social associations were explored for identified QoL impairments. Results. In total, 74/90 (82%) cases and 781/2000 (39%) controls participated. Cases reported a significant impairment in physical health (P < 0.0001), but not mental health (P = 0.85), compared with controls, as measured by Short Form-8 (SF-8). Following adjustment for age and sex, persons with AAV were more than tw

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Author

N. Basu; G. T. Jones; N. Fluck; A. G. MacDonald; D. Pang; P. Dospinescu; D. M. Reid; G. J. Macfarlane

Publisher

Oxford University Press (OUP)

Published

2010

Language

EN

Field

Medicine (Health Sciences)