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The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma by Carles Martínez‐Romero; Ilse Rooman; Anouchka Skoudy; Carmen Guerra; Xavier Molero; Ana González; Mar Iglesias; Tania Lobato; Almudena Bosch; Mariano Barbacid; Francisco X Real; Inmaculada Hernández‐Muñoz is a Medicine article available to read on EtoBox.

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## Abstract Chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are associated with major changes in cell differentiation. These changes may be at the basis of the increased risk for PDAC among patients with chronic pancreatitis. Polycomb proteins are epigenetic silencers expressed in adult stem cells; up‐regulation of Polycomb proteins has been reported to occur in a variety of solid tumours such as colon and breast cancer. We hypothesized that Polycomb might play a role in preneoplastic states in the pancreas and in tumour development/progression. To test these ideas, we determined the expression of PRC1 complex proteins (Bmi1 and Ring1b) during pancreatic development and in pancreatic tissue from mouse models of disease: acute and chronic pancreatic injury, duct ligation, and in K‐__Ras__^__G__12__V__^ conditional knock‐in and caerulein‐treated K‐__Ras__^__G__12__V__^ mice. The study was extended to human pancreatic tissue samples. To obtain mechanistic insights, Bmi1 expression in cells undergoing __in vitro__ exocrine cell metaplasia and the effects of Bmi1 depletion in an acinar cancer cell line were studied. We found that Bmi1 and Ring1B are expressed in pancrea

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Author

Carles Martínez‐Romero; Ilse Rooman; Anouchka Skoudy; Carmen Guerra; Xavier Molero; Ana González; Mar Iglesias; Tania Lobato; Almudena Bosch; Mariano Barbacid; Francisco X Real; Inmaculada Hernández‐Muñoz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2009

Language

EN

Field

Medicine (Health Sciences)