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This study investigates the pharmacokinetics and pharmacodynamics of rituximab in patients with acute idiopathic thrombotic thrombocytopenic purpura (TTP) undergoing plasma exchange (PEX). Results indicate that rituximab levels are significantly reduced during PEX, affecting treatment response, with a median of 10 PEX sessions required for remission. The findings suggest that while rituximab can help reduce relapse rates, its effectiveness may be compromised by its removal during PEX.

Author

pablogomiero

Language

EN