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Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in mice by Wang, Yang; Lobigs, Mario; Lee, Eva; Mullbacher, Arno is a Immunology and Microbiology article available to read on EtoBox.

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Infection of mice with the flaviviruses West Nile virus (WNV) and Murray Valley encephalitis (MVE) induces cytolytic T‐cell responses which are highly cross‐reactive on target cells infected with heterologous flaviviruses. Of C57BL/6 mice infected with low doses (10^2^−10^6^ PFU) of either virus, 30−40% develop encephalitis and die within 10−12 days^1^, ^2^. Mice with defects in the Fas or granule exocytosis (perforin and granzymes A and B) pathway of cellular cytotoxicity display reduced mortality and increased survival time when infected with MVE and are protected from encephalitis when deficient in both pathways. This contrasts with infection with WNV where defects in these cytolytic mechanisms increase the percentage of mice that succumb to encephalitis. Thus, no generalizations as to protective or detrimental effects of cytolytic effector functions in recovery from closely related flavivirus infections can be made. Virus−host immune interactions have to be assessed individually and cannot be generalized.

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Author

Wang, Yang; Lobigs, Mario; Lee, Eva; Mullbacher, Arno

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); John Wiley and Sons Inc.; Wiley (ISSN 0818-9641)

Published

2004

Language

EN

Field

Immunology and Microbiology (Life Sciences)