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The study investigates the enhanced solubility of ibuprofen (IBU) through complexation with β-cyclodextrin (β-CD) and citric acid (CA). Various synthetic methods, including mechanical milling and thermal annealing, were employed to form inclusion complexes, resulting in improved dissolution kinetics of the ternary β-CD/IBU/CA complex compared to pure IBU and the binary β-CD/IBU system. The findings suggest that while CA does not significantly increase IBU

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drxgourav018

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EN