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Quantitative background parenchymal enhancement and fibro-glandular density at breast MRI: Association with BRCA status by Rosie Goodburn; Evanthia Kousi; Clarrissa Sanders; Alison Macdonald; Erica Scurr; Catey Bunce; Komel Khabra; Mamatha Reddy; Louise Wilkinson; Elizabeth O’Flynn; Steven Allen; Maria Angélica Schmidt is a Medicine article available to read on EtoBox.

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## Objectives To investigate whether MRI-based measurements of fibro-glandular tissue volume, breast density (MRBD), and background parenchymal enhancement (BPE) could be used to stratify two cohorts of healthy women: BRCA carriers and women at population risk of breast cancer. ## Methods Pre-menopausal women aged 40–50 years old were scanned at 3 T, employing a standard breast protocol including a DCE-MRI (35 and 30 participants in high- and low-risk groups, respectively). The dynamic range of the DCE protocol was characterised and both breasts were masked and segmented with minimal user input to produce measurements of fibro-glandular tissue volume, MRBD, and voxelwise BPE. Statistical tests were performed to determine inter- and intra-user repeatability, evaluate the symmetry between metrics derived from left and right breasts, and investigate MRBD and BPE differences between the high- and low-risk cohorts. ## Results Intra- and inter-user reproducibility in estimates of fibro-glandular tissue volume, MRBD, and median BPE estimations were good, with coefficients of variation < 15%. Coefficients of variation between left and right breasts were also low (< 25%). There were no sign

Who reads Quantitative background parenchymal enhancement and fibro-glandular density at breast MRI: Association with BRCA status?

Author

Rosie Goodburn; Evanthia Kousi; Clarrissa Sanders; Alison Macdonald; Erica Scurr; Catey Bunce; Komel Khabra; Mamatha Reddy; Louise Wilkinson; Elizabeth O’Flynn; Steven Allen; Maria Angélica Schmidt

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)