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Multiple drugs Anaphylaxis and systemic allergic reaction to polyethylene glycol excipient: 5 case reports In a case series, four women and one man aged 20-70 years were described, who developed anaphylaxis or systemic allergic reaction during treatment with aspirin, atovaquone/proguanil, bisacodyl, calcium-carbonate/sodium-bicarbonate/sodium-alginate, clopidogrel, medroxyprogesterone, methylprednisolone-acetate, PEG-3350/sodium-chloride/sodium-sulfate/potassium-chloride/ ascorbic-acid or phenoxymethylpenicillin. Both anaphylaxis and systemic allergic reaction were attributed to the excipient polyethylene glycol (PEG) in the medication [routes and dosages not stated; not all indications, duration of treatments to reactions onsets and outcomes stated].Case 1: A 51-year-old woman, who had a history of contact dermatitis to cosmetics, presented with anaphylaxis to medroxyprogesterone containing PEG 3350 and polysorbate 80 [medroxyprogesterone acetate; Depo-Provera; Pfizer] and a systemic allergic reaction to the laxative PEG-3350/sodium-chloride/sodium-sulfate/potassium-chloride/ascorbic-acid containing Norgine]. Within minutes of receiving medroxyprogesterone, she developed light-hea

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Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)