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This study investigates the synthesis and biological activities of novel piperidyl-thienyl chalcones and their 2-pyrazoline derivatives, focusing on their anti-HIV-1 and cytotoxic effects. Twelve new pyrazoline derivatives were prepared and screened, with several compounds showing promising anti-HIV-1 activity while maintaining low cytotoxicity. The results indicate that the type and position of substituents significantly influence the biological activities of these compounds.

Author

sofacomsofacom1

Language

EN