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Can I read Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer on EtoBox?
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer by Jing Shan Lim; Alvaro Ibaseta; Marcus M. Fischer; Belinda Cancilla; Gilbert O’Young; Sandra Cristea; Vincent C. Luca; Dian Yang; Nadine S. Jahchan; Cécile Hamard; Martine Antoine; Marie Wislez; Christina Kong; Jennifer Cain; Yu-Wang Liu; Ann M. Kapoun; K. Christopher Garcia; Timothy Hoey; Christopher L. Murriel; Julien Sage is a Physics and Astronomy article available to read on EtoBox.
What is Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer about?
The Notch signalling pathway mediates cell fate decisions and is tumour suppressive or oncogenic depending on the context. During lung development, Notch pathway activation inhibits the differentiation of precursor cells to a neuroendocrine fate. In small-cell lung cancer, an aggressive neuroendocrine lung cancer, loss-of-function mutations in NOTCH genes and the inhibitory effects of ectopic Notch activation indicate that Notch signalling is tumour suppressive. Here we show that Notch signalling can be both tumour suppressive and pro-tumorigenic in small-cell lung cancer. Endogenous activation of the Notch pathway results in a neuroendocrine to non-neuroendocrine fate switch in 10-50% of tumour cells in a mouse model of small-cell lung cancer and in human tumours. This switch is mediated in part by Rest (also known as Nrsf), a transcriptional repressor that inhibits neuroendocrine gene expression. Non-neuroendocrine Notch-active small-cell lung cancer cells are slow growing, consistent with a tumour-suppressive role for Notch, but these cells are also relatively chemoresistant and provide trophic support to neuroendocrine tumour cells, consistent with a pro-tumorigenic role. Impor
Who reads Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer?
It is typically read by researchers, students, and practitioners in Physics and Astronomy.
- Author
- Jing Shan Lim; Alvaro Ibaseta; Marcus M. Fischer; Belinda Cancilla; Gilbert O’Young; Sandra Cristea; Vincent C. Luca; Dian Yang; Nadine S. Jahchan; Cécile Hamard; Martine Antoine; Marie Wislez; Christina Kong; Jennifer Cain; Yu-Wang Liu; Ann M. Kapoun; K. Christopher Garcia; Timothy Hoey; Christopher L. Murriel; Julien Sage
- Publisher
- Springer Science and Business Media LLC
- Published
- 2017
- Language
- EN
- Field
- Physics and Astronomy (Physical Sciences)