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Network Pharmacology-based Screening of the Active Ingredients and Mechanisms of Evodiae Fructus Anti-glioblastoma Multiforme by Gang Wu; Qingpei Hao; Bo Liu; Jingru Zhou; Cungang Fan; Ruen Liu is a Medicine article available to read on EtoBox.

What is Network Pharmacology-based Screening of the Active Ingredients and Mechanisms of Evodiae Fructus Anti-glioblastoma Multiforme about?

## Background: Evodiae fructus has been shown to have anti-glioblastoma multiforme (GBM) effects. However, its anti-GBM active components and mechanism remain unclear. In this study, the active components of evodiae fructus were screened by network pharmacology to explore the possible molecular mechanism of resistance to GBM. ## Materials and methods: The main active ingredients of evodiae fructus were derived from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and Batch-traditional Chinese medicine (TCM). TCMSP and Swiss absorption, distribution, metabolism and elimination (ADME) predict genetic targets for ingredients that meet pharmacological criteria. GBM-related targets were obtained from DisGeNet, GeneCards, Online Mendelian Inheritance in Man (OMIM), Therapeutic Target Database (TTD), and TCGA. A Venn diagram was used to obtain the common targets of evodiae fructus and GBM. Protein–protein interaction (PPI) networks and component-disease target networks were constructed using Cytoscape 3.8.1 software for visualization. GBM gene differential expression was visualized by VolcaNoseR, and potential targets were enriched by Gene Ontology

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Author

Gang Wu; Qingpei Hao; Bo Liu; Jingru Zhou; Cungang Fan; Ruen Liu

Published

2022

Language

EN

Field

Medicine (Health Sciences)