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Can I read The Cost-Effectiveness of Acetaminophen, NSAIDs, and Selective COX-2 Inhibitors in the Treatment of Symptomatic Knee Osteoarthritis on EtoBox?
The Cost-Effectiveness of Acetaminophen, NSAIDs, and Selective COX-2 Inhibitors in the Treatment of Symptomatic Knee Osteoarthritis by Celia C. Kamath; Hilal Maradit Kremers; David J. Vanness; W. Michael O'Fallon; Rosa L. Cabanela; Sherine E. Gabriel is a Economics, Econometrics and Finance article available to read on EtoBox.
What is The Cost-Effectiveness of Acetaminophen, NSAIDs, and Selective COX-2 Inhibitors in the Treatment of Symptomatic Knee Osteoarthritis about?
## Objective: The objective of this study was to conduct an economic evaluation of rofecoxib and celecoxib compared with high-dose acetaminophen or ibuprofen with and without misoprostol for patients with symptomatic knee osteoarthritis (oa). ## Methods: A decision analysis model was designed over 6 months using two measures of effectiveness: 1) number of upper gastrointestinal (gi) adverse events averted; and 2) number of patients who achieved perceptible pain relief. separate analyses were conducted for all patients and for those who did not respond to acetaminophen. outcome probabilities were obtained from a comprehensive review of randomized controlled trials and observational studies. costs were derived from actual resource utilization of oa patients. ## Results: In terms of averting gi events, acetaminophen dominates the other options for an average risk patient population. for patients who did not respond to acetaminophen, rofecoxib had the lowest incremental cost-effectiveness ratio (icer) per gi event avoided (32,000 us dollars) relative to ibuprofen. in terms of pain control, ibuprofen had an icer of 610.77 us dollars per additional patient achieving minimal perceptible c
Who reads The Cost-Effectiveness of Acetaminophen, NSAIDs, and Selective COX-2 Inhibitors in the Treatment of Symptomatic Knee Osteoarthritis?
It is typically read by researchers, students, and practitioners in Economics, Econometrics and Finance.
- Author
- Celia C. Kamath; Hilal Maradit Kremers; David J. Vanness; W. Michael O'Fallon; Rosa L. Cabanela; Sherine E. Gabriel
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 1098-3015)
- Published
- 2003
- Language
- EN
- Field
- Economics, Econometrics and Finance (Social Sciences)