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Resveratrol delays polycystic kidney disease progression through attenuation of nuclear factor κB-induced inflammation by Ming Wu; Junhui Gu; Shuqin Mei; Dechao Xu; Ying Jing; Qing Yao; Meihan Chen; Ming Yang; Sixiu Chen; Bo Yang; Na Qi; Huimin Hu; Rudolf P. Wüthrich; Changlin Mei is a Medicine article available to read on EtoBox.

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## Background: Inflammation plays an important role in polycystic kidney disease (pkd). the current study aimed to examine the efficacy of the anti-inflammatory compound resveratrol in pkd and to investigate its underlying mechanism of action. ## Methods: Male han:sprd (cy/+) rats with pkd were treated with 200 mg/kg/day resveratrol or vehicle by gavage for 5 weeks. human autosomal dominant (ad) pkd cells, three-dimensional (3d) madin-darby canine kidney cells and zebrafish were treated with various concentrations of resveratrol or the nuclear factor κb (nf-κb) inhibitor qnz. ## Results: Resveratrol treatment reduced blood urea nitrogen levels and creatinine levels by 20 and 24%, respectively, and decreased two-kidney/total body weight ratio by 15% and cyst volume density by 24% in cy/+ rats. the proliferation index and the macrophage infiltration index were reduced by 40 and 43%, respectively, in resveratrol-treated cystic kidneys. resveratrol reduced the levels of the pro-inflammatory factors monocyte chemoattractant protein-1 (mcp-1), tumor necrosis factor-α (tnf-α) and complement factor b (cfb) in cy/+ rat kidneys in parallel with the decreased activity of nf-κb (p50/p65). the

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Author

Ming Wu; Junhui Gu; Shuqin Mei; Dechao Xu; Ying Jing; Qing Yao; Meihan Chen; Ming Yang; Sixiu Chen; Bo Yang; Na Qi; Huimin Hu; Rudolf P. Wüthrich; Changlin Mei

Published

2016

Language

EN

Field

Medicine (Health Sciences)