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Advancements in Programmable Lipid Nanoparticles: Exploring the Four-Domain Model for Targeted Drug Delivery by Liu, Zhaoyu; Chen, Jingxun; Xu, Mingkun; Gracias, David H.; Yong, Ken-Tye; Wei, Yuanyuan; Ho, Ho-Pui is a scholarly article available to read on EtoBox.

What is Advancements in Programmable Lipid Nanoparticles: Exploring the Four-Domain Model for Targeted Drug Delivery about?

Programmable lipid nanoparticles, or LNPs, represent a breakthrough in the realm of targeted drug delivery, offering precise spatiotemporal control essential for the treatment of complex diseases such as cancer and genetic disorders. In order to provide a more modular perspective and a more balanced analysis of the mechanism, this review presents a novel Four-Domain Model that consists of Architecture, Interface, Payload, and Dispersal Domain. We explored the dynamical equilibrium between LNPs components and the surroundings throughout their destiny, from formulation to release. On the basis of this, we delve deep into manufacturing challenges, scalability issues, and regulatory hurdles, associated with the clinical translation of LNP technology. Within the framework focusing on the programmability in each domain, we prioritized patient-centric factors like dosing regimens, administration techniques, and potential consequences. Notably, this review expands to innovative anatomical routes, such as intranasal and intraocular administration, offering a thorough examination of the advantages and disadvantages of each route. We also offered a comprehensive comparison between artificial

Author

Liu, Zhaoyu; Chen, Jingxun; Xu, Mingkun; Gracias, David H.; Yong, Ken-Tye; Wei, Yuanyuan; Ho, Ho-Pui

Published

2024

Language

EN