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Myelin‐associated Oligodendrocytic Basic Protein Is Essential for Normal Arrangement of the Radial Component in Central Nervous System Myelin by Yoichi Yamamoto; Hiroo Yoshikawa; Seiichi Nagano; Gen Kondoh; Shigeki Sadahiro; Takahiro Gotow; Takehiko Yanagihara; Saburo Sakoda is a Neuroscience article available to read on EtoBox.

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## Abstract We previously reported that myelin‐associated oligodendrocytic basic protein (MOBP) was abundantly expressed in the central nervous system (CNS) myelin, and shared several characteristics with myelin basic protein (MBP). In particular, a cluster of positively charged amino acids was considered to facilitate compaction of the cytoplasmic face of the myelin sheath, as in the case of MBP. However, the contribution of MOBP in forming and maintaining the myelin sheath still remains unclear. Recent investigations showed that one isoform of MOBP was expressed in the embryo prior to myelination, and MOBP isoforms were colocalized with the microtubular network and nucleus __in vitro__. To explore the role of MOBP __in vivo__, we generated MOBP‐deficient mice and analysed the CNS myelin. Surprisingly, the compact myelin was formed, however, the myelin from MOBP‐deficient mice exposed to hexachlorophene, a known dysmyelinating agent, showed widening of the major dense lines. These results suggest that MOBP is not essential for myelin formation, but reinforces the apposition of the cytoplasmic faces of the myelin sheath. A striking phenotype of MOBP‐deficient mice was the presence

Who reads Myelin‐associated Oligodendrocytic Basic Protein Is Essential for Normal Arrangement of the Radial Component in Central Nervous System Myelin?

Author

Yoichi Yamamoto; Hiroo Yoshikawa; Seiichi Nagano; Gen Kondoh; Shigeki Sadahiro; Takahiro Gotow; Takehiko Yanagihara; Saburo Sakoda

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

1999

Language

EN

Field

Neuroscience (Life Sciences)