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Low Dose Lead Exposure at the Onset of Puberty Disrupts Spermatogenesis-related Gene Expression and Causes Abnormal Spermatogenesis in Mouse by Xie, Jie; Yu, Jun; Fan, Yongsheng; Zhao, Xue; Su, Jianmei; Meng, Yu; Wu, Yu; Uddin, Mohammad Burhan; Wang, Chunhong; Wang, Zhishan is a Environmental Science article available to read on EtoBox.
What is Low Dose Lead Exposure at the Onset of Puberty Disrupts Spermatogenesis-related Gene Expression and Causes Abnormal Spermatogenesis in Mouse about?
Implications of lead (Pb) exposure in dysregulated spermatogenesis in sexually active individuals during adulthood is well established; however, the effect of Pb exposure on spermatogenesis in the early stages of puberty is not clear yet. Moreover, the mechanism of Pb mediated dysregulation of spermatogenesis in adults is also poorly understood. Exposure to environmental toxicants during puberty may cause serious consequences in adulthood causing developmental retardations, especially in the reproductive system. Here we investigated the effects of lead exposure on spermatogenesis at the onset of puberty and the underlying mechanisms of these effects. Male ICR mice were exposed to low (50 mg/L) and high (200 mg/L) doses of Pb through the drinking water for 90 days. At the end of this period, the blood Pb level of the low-dose and high-dose exposure groups were found 6.14 ± 0.34 μg/dL and 11.92 ± 2.92 μg/dL respectively which were in agreement with the US CDC-recommended (5 μg/dL) and Chinese CDC-recommended (10 μg/dL) reference blood Pb level for the children. Although no visible toxicity was observed in either group, Pb exposure caused considerable histopathological changes in test
Who reads Low Dose Lead Exposure at the Onset of Puberty Disrupts Spermatogenesis-related Gene Expression and Causes Abnormal Spermatogenesis in Mouse?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Xie, Jie; Yu, Jun; Fan, Yongsheng; Zhao, Xue; Su, Jianmei; Meng, Yu; Wu, Yu; Uddin, Mohammad Burhan; Wang, Chunhong; Wang, Zhishan
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0041-008X)
- Published
- 2020
- Language
- EN
- Field
- Environmental Science (Life Sciences)