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Can I read Arsenic trioxide sensitizes CD95/Fas-induced apoptosis through ROS-mediated upregulation of CD95/Fas by NF-κB activation on EtoBox?
Arsenic trioxide sensitizes CD95/Fas-induced apoptosis through ROS-mediated upregulation of CD95/Fas by NF-κB activation by Sang Hyeok Woo; In-Chul Park; Myung-Jin Park; Sungkwan An; Hyung-Chahn Lee; Hyeon-Ok Jin; Sin-Ae Park; Hyeyoung Cho; Su-Jae Lee; Ho-Shin Gwak; Young-Joon Hong; Seok-Il Hong; Chang Hun Rhee is a Medicine article available to read on EtoBox.
What is Arsenic trioxide sensitizes CD95/Fas-induced apoptosis through ROS-mediated upregulation of CD95/Fas by NF-κB activation about?
## Abstract CD95/Fas is a cell surface protein that belongs to the tumor necrosis factor receptor family. Signals through CD95/Fas are able to induce apoptosis in sensitive cells. Therefore, modalities to regulate the CD95/Fas expression level in tumor cells are called for. In the present study, we show that sublethal doses of arsenic trioxide (As~2~O~3~) sensitized CD95/Fas‐induced apoptosis in human cervical cancer cells, and the sensitizing effects resulted from As~2~O~3~‐mediated increase in the expression of the CD95/Fas. N‐acetyl‐__L__‐cysteine, a specific scavenger of reactive oxygen species, abrogated As~2~O~3~‐induced upregulation of CD95/Fas and enhancement of CD95/Fas‐mediated apoptosis. Furthermore, inhibition of NF‐κB by transient transfection of IκBα supersuppressor blocked the increase of CD95/Fas expression following As~2~O~3~ treatment. Antisense oligonucleotide of CD95/Fas and ZB4, an antibody that blocks the binding of CD95/Fas ligand to CD95/Fas, reduced the amount of As~2~O~3~‐sensitized CD95/Fas‐induced apoptosis, demonstrating the specificity of CD95/Fas‐binding ligands in the As~2~O~3~‐sensitized CD95/Fas‐induced apoptosis. These findings demonstrate that se
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- Author
- Sang Hyeok Woo; In-Chul Park; Myung-Jin Park; Sungkwan An; Hyung-Chahn Lee; Hyeon-Ok Jin; Sin-Ae Park; Hyeyoung Cho; Su-Jae Lee; Ho-Shin Gwak; Young-Joon Hong; Seok-Il Hong; Chang Hun Rhee
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)