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Can I read Mitochondrial Dysfunction and Acute Fatty Liver of Pregnancy on EtoBox?
Mitochondrial Dysfunction and Acute Fatty Liver of Pregnancy by Raghu Ramanathan; Jamal A. Ibdah is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mitochondrial Dysfunction and Acute Fatty Liver of Pregnancy about?
The liver is one of the richest organs in mitochondria, serving as a hub for key metabolic pathways such as β-oxidation, the tricarboxylic acid (TCA) cycle, ketogenesis, respiratory activity, and adenosine triphosphate (ATP) synthesis, all of which provide metabolic energy for the entire body. Mitochondrial dysfunction has been linked to subcellular organelle dysfunction in liver diseases, particularly fatty liver disease. Acute fatty liver of pregnancy (AFLP) is a life-threatening liver disorder unique to pregnancy, which can result in serious maternal and fetal complications, including death. Pregnant mothers with this disease require early detection, prompt delivery, and supportive maternal care. AFLP was considered a mysterious illness and though its pathogenesis has not been fully elucidated, molecular research over the past two decades has linked AFLP to mitochondrial dysfunction and defects in fetal fatty-acid oxidation (FAO). Due to deficient placental and fetal FAO, harmful 3-hydroxy fatty acid metabolites accumulate in the maternal circulation, causing oxidative stress and microvesicular fatty infiltration of the liver, resulting in AFLP. In this review, we provide an ove
Who reads Mitochondrial Dysfunction and Acute Fatty Liver of Pregnancy?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Raghu Ramanathan; Jamal A. Ibdah
- Publisher
- MDPI AG
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)