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In Vitro Degradation and in Vivo Biocompatibility Study of a New Linear Poly(urethane Urea) by Basse Asplund; Cecilia Aulin; Tim Bowden; Niklas Eriksson; Torbjörn Mathisen; Lars‐Magnus Bjursten; Jöns Hilborn is a Medicine article available to read on EtoBox.

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## Abstract Segmented poly(urethane urea)s (PUUs) with hard segments derived only from methyl 2,6‐diisocyantohexanoate (LDI) without the use of a chain extender have previously been described. These materials, which contain hard segments with multiple urea linkages, show exceptionally high strain capability (1600–4700%). In the study reported here, the rate and effect of hydrolysis of these materials were determined for gamma‐sterilized and nonsterilized samples. Materials investigated contained PCL, PTMC, P(TMC‐__co__‐CL), P(CL‐__co__‐DLLA), or P(TMC‐__co__‐DLLA) as soft segments and, as well as their mechanical properties, changes in mass, inherent viscosity (I.V.), and thermal properties were studied over 20 weeks. Results showed that the degradation rate was dependant on the soft segment structure, with a higher rate of degradation for the polyester‐dominating PUUs exhibiting a substantial loss in I.V. A tendency of reduction of tensile strength and strain hardening was seen for all samples. Also, loss in elongation at break was detected, for PUU‐P(CL‐DLLA) it went from 1600% to 830% in 10 weeks. Gamma radiation caused an initial loss in I.V. and induced more rapid hydrolysis c

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Author

Basse Asplund; Cecilia Aulin; Tim Bowden; Niklas Eriksson; Torbjörn Mathisen; Lars‐Magnus Bjursten; Jöns Hilborn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1552-4973)

Published

2007

Language

EN

Field

Medicine (Health Sciences)