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A comparative trial of LC9018 plus doxorubicin and doxorubicin alone for the treatment of malignant pleural effusion secondary to lung cancer by Tomiya Masuno; Susumu Kishimoto; Takeshi Ogura; Takeshi Honma; Hisanobu Niitani; Masahiro Fukuoka; Nobuya Ogawa is a Medicine article available to read on EtoBox.
What is A comparative trial of LC9018 plus doxorubicin and doxorubicin alone for the treatment of malignant pleural effusion secondary to lung cancer about?
The efficacy and safety of intrapleural LC9018 (Yakult Co. Ltd., Tokyo, Japan) with or without doxorubicin (Adriamycin; Adria Laboratories, Columbus, OH) were evaluated in a randomized, controlled trial performed in 95 patients with malignant pleural effusions secondary to lung cancer. Seventy-six patients were eligible for the assessment of efficacy. The response rate for treatment with intrapleural doxorubicin plus LC9018 (38 patients) was 73.770, which was significantly higher than the response rate of 39.5% for the control group treated with doxorubicin alone (38 patients) (P < 0.01). The L O 1 8 group also showed a significantly greater improvement in performance status (PS) and symptoms (chest pain, chest discomfort, and anorexia) than the control group (P < 0.05). A significant prolongation of survival was noticed in the LC9018 group ( P < 0.05). The main side effects of L O 1 8 were fever and transient hepatic dysfunction, but there were no serious adverse reactions. These results suggest that the intrapleural instillation of LC9018 can be recommended for the treatment of malignant pleural effusions. Cancer 683495-1500,1991. ALIGNANT PLEURAL EFFUSION is a common com-M plica
Who reads A comparative trial of LC9018 plus doxorubicin and doxorubicin alone for the treatment of malignant pleural effusion secondary to lung cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Tomiya Masuno; Susumu Kishimoto; Takeshi Ogura; Takeshi Honma; Hisanobu Niitani; Masahiro Fukuoka; Nobuya Ogawa
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 1991
- Language
- EN
- Field
- Medicine (Health Sciences)