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Particle‐mediated Gene Therapy of Wounds by Jeffrey M Davidson; Thomas Krieg; Sabine A Eming is a Medicine article available to read on EtoBox.

What is Particle‐mediated Gene Therapy of Wounds about?

Gene therapy is becoming a reality, and it is a particularly attractive approach for wound healing, because the wound site is often exposed, the treatment and condition should be transient, and gene products such as growth factors and cytokines suffer from problems with bioavailability and stability. Among the techniques for gene delivery to the wound site, particle‐mediated bombardment with a device called the gene gun has become an important developmental tool. This instrument has been used in numerous examples of wound gene therapy with growth factors or their receptors in the last decade. Among the advantages of particle‐mediated bombardment are ease and speed of preparation of the delivery vehicle, the stability of the DNA preparation, the absence of (viral) antigens, the ability to target the projectiles to different tissue depths and areas, and the rapid shedding of both particles and DNA if they are targeted to the epidermis. Clinical application of the technology remains limited by the relatively low efficiency of the method, the potential tissue damage created by impact of the particles, and the coverage area. The gene gun can also be used to facilitate the discovery and

Who reads Particle‐mediated Gene Therapy of Wounds?

Author

Jeffrey M Davidson; Thomas Krieg; Sabine A Eming

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1067-1927)

Published

2000

Language

EN

Field

Medicine (Health Sciences)