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Investigating the Moisture-induced Crystallization Kinetics of Spray-dried Lactose by D.J. Burnett; F. Thielmann; T. Sokoloski; J. Brum is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Investigating the Moisture-induced Crystallization Kinetics of Spray-dried Lactose about?

Gravimetric water sorption experiments were performed to study the crystallization behavior of amorphous spray-dried lactose over a wide range of temperature and humidity conditions. Experiments performed at 25 • C between 48 and 60% relative humidity (RH) showed that the onset time to crystallization increased dramatically with decreasing humidity. At 55% RH and above, crystallization occurred in a single detectible step, while below a two-step process was observed. Experiments performed at 51% RH between 22 and 32 • C indicated the induction time to crystallization onset increased with decreasing temperature. Above 25 • C at 51% RH, crystallization occurred in one measurable step, while below crystallization occurred in two steps. The constant RH with varying temperature results were modeled to determine the crystallization mechanism. Above 25 • C a mechanism consisting of two competing reaction sequences fit the data with a 0.9997 correlation coefficient. Both reaction sequences have two steps: an auto-catalytic first step is followed by a three-dimensional diffusion controlled water loss step.

Who reads Investigating the Moisture-induced Crystallization Kinetics of Spray-dried Lactose?

Author

D.J. Burnett; F. Thielmann; T. Sokoloski; J. Brum

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2006

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)