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Nanotechnology in Insulin Delivery for Management of Diabetes by Fatemah Bahman; Khaled Greish; Sebastien Taurin is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Nanotechnology in Insulin Delivery for Management of Diabetes about?

## Diabetes is a group of diseases characterized by hyperglycemia and originating from the deficiency or resistance to insulin, or both. Ultimately, the most effective treatment for patients with diabetes involves subcutaneous injections of insulin. However, this route of administration is often painful and inconvenient, as most patients will have to selfadminister it at least twice a day for the rest of their lives. Also, infection, insulin precipitation, and either lipoatrophy or lipohypertrophy are frequently observed at the site of injection. To date, several alternative routes of insulin administration have been explored, including nasal, pulmonary and oral. Although the delivery of insulin is an ideal route for diabetic patients, several limitations have to be overcome such as the rapid degradation of insulin in gastric fluid and low oral bioavailability. Numerous strategies have been carried out to improve these limited parameters such as the use of enzyme inhibitors, absorption enhancers, mucoadhesive polymers and chemical modification for receptor-mediated absorption. Also, insulin-loaded nanocarriers bypass several physiological barriers. This current review focuses on th

Who reads Nanotechnology in Insulin Delivery for Management of Diabetes?

Author

Fatemah Bahman; Khaled Greish; Sebastien Taurin

Publisher

Bentham Science Publishers Ltd.

Published

2019

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)