Opening book details…
Can I read The clinical phenotype of children with Fanconi anemia caused by biallelic FANCD1/BRCA2 mutations on EtoBox?
The clinical phenotype of children with Fanconi anemia caused by biallelic FANCD1/BRCA2 mutations by Kasiani Myers; Stella M. Davies; Richard E. Harris; Sheri L. Spunt; Teresa Smolarek; Sarah Zimmerman; Richard McMasters; Lars Wagner; Robin Mueller; Arleen D. Auerbach; Parinda A. Mehta is a Medicine article available to read on EtoBox.
What is The clinical phenotype of children with Fanconi anemia caused by biallelic FANCD1/BRCA2 mutations about?
## Abstract Fanconi anemia (FA) is characterized by progressive marrow failure, congenital anomalies, and predisposition to malignancy. Biallelic __FANCD1/BRCA2__ mutations are the genetic basis of disease in a small proportion of children with FA with earlier onset and increased incidence of leukemia and solid tumors. Patients with FA have increased sensitivity to chemotherapy and radiation, and upon development of a solid tumor, require modification of these therapies. We report clinical and molecular features of three patients with FA associated with __FANCD1/BRCA2__ mutations, including two novel mutations, and discuss treatment of malignancy and associated side effects in this particularly vulnerable group. Pediatr Blood Cancer 2012; 58: 462–465. © 2011 Wiley Periodicals, Inc.
Who reads The clinical phenotype of children with Fanconi anemia caused by biallelic FANCD1/BRCA2 mutations?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kasiani Myers; Stella M. Davies; Richard E. Harris; Sheri L. Spunt; Teresa Smolarek; Sarah Zimmerman; Richard McMasters; Lars Wagner; Robin Mueller; Arleen D. Auerbach; Parinda A. Mehta
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)