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Can I read Molecular cytogenetic characterization of an acquired minute supernumerary marker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia on EtoBox?
Molecular cytogenetic characterization of an acquired minute supernumerary marker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia by Heike Starke; Martin Raida; Vladimir Trifonov; Joachim H. Clement; Ivan F. Loncarevic; Anita Heller; Cordula Bleck; Angela Nietzel; Nikolai Rubtsov; Uwe Claussen; Thomas Liehr is a Medicine article available to read on EtoBox.
What is Molecular cytogenetic characterization of an acquired minute supernumerary marker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia about?
A case of chronic myelogenous leukaemia (CML) in a 48-year-old man is reported. To the best of our knowledge, this is the first report of a Philadelphia-negative CML with an acquired small supernumerary marker chromosome (SMC) 11 as the sole abnormality. The derivative chromosome 11 was studied in detail using molecular cytogenetic methods; fluorescence in situ hybridization (FISH) using centromere- and region-specific probes for chromosome 11, microdissection, micro-comparative genomic hybridization (micro-CGH) and the recently developed multicolour banding (MCB) technique. The acquired SMC was determined to be a ring chromosome that can be described as r(11)(:p11.2-->q13.1:q14:).
Who reads Molecular cytogenetic characterization of an acquired minute supernumerary marker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Heike Starke; Martin Raida; Vladimir Trifonov; Joachim H. Clement; Ivan F. Loncarevic; Anita Heller; Cordula Bleck; Angela Nietzel; Nikolai Rubtsov; Uwe Claussen; Thomas Liehr
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)