Can I read Facile Synthesis and Cleavage of Imidazolidines in a Novel Protection Strategy for the Preparation of Peptides Containing a Reduced Amide Bioisostere on EtoBox?

Facile Synthesis and Cleavage of Imidazolidines in a Novel Protection Strategy for the Preparation of Peptides Containing a Reduced Amide Bioisostere by Jun Zhao; Vatee Pattaropong; Yongying Jiang; Longqin Hu is a Chemistry article available to read on EtoBox.

What is Facile Synthesis and Cleavage of Imidazolidines in a Novel Protection Strategy for the Preparation of Peptides Containing a Reduced Amide Bioisostere about?

Unsymmetrical imidazolidines were obtained in 75-91% yield by treating monoalkoxycarbonyl vicinal diamines at room temperature with aqueous 37% formaldehyde in the presence of Montmorillonite KSF as a solid catalyst. The imidazolidines were shown to be useful intermediates in a novel protection strategy for the synthesis of peptide analogues containing a reduced glycine amide bioisostere. The imidazolidine intermediate was cleaved conveniently and efficiently by 50% TFA in methylene chloride.

Who reads Facile Synthesis and Cleavage of Imidazolidines in a Novel Protection Strategy for the Preparation of Peptides Containing a Reduced Amide Bioisostere?

Author

Jun Zhao; Vatee Pattaropong; Yongying Jiang; Longqin Hu

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

2003

Language

EN

Field

Chemistry (Physical Sciences)