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MR imaging in Duchenne muscular dystrophy: Quantification of T~1~‐weighted signal, contrast uptake, and the effects of exercise by Penelope Garrood; Kieren G. Hollingsworth; Michelle Eagle; Benjamin S. Aribisala; Daniel Birchall; Kate Bushby; Volker Straub is a Medicine article available to read on EtoBox.

What is MR imaging in Duchenne muscular dystrophy: Quantification of T~1~‐weighted signal, contrast uptake, and the effects of exercise about?

## Abstract ## Purpose: To quantify the differences between normal and corticosteroid‐treated Duchenne muscular dystrophy (DMD) lower limb muscle using signal intensity measurements on T~1~‐weighted and gadolinium contrast‐enhanced images and by measurement of muscle T~2~ values, and to investigate the effect of exercise. ## Materials and Methods: Eleven ambulant boys with DMD were imaged at 3 Tesla (T~1~‐weighted, gadolinium enhancement and T~2~ measurement) before stepping exercise and again (gadolinium, T~2~ measurement) 4 days later and were compared with five healthy controls imaged 4 days before and after stepping exercise. Muscle region‐of‐interest signal intensities were referenced to external oil and gadolinium phantoms. ## Results: DMD thigh muscle T~2~ values were significantly higher than normal values with the exception of the gracilis muscle. Eight of nine muscles studied showed a significant increase in T~1~‐w signal intensity in DMD as compared to normal muscle, suggestive of increased fat infiltration in DMD muscle. In the DMD boys, an exercise effect (increased contrast enhancement) was only seen for the tibialis anterior muscle. ## Conclusion: Referenced signal i

Who reads MR imaging in Duchenne muscular dystrophy: Quantification of T~1~‐weighted signal, contrast uptake, and the effects of exercise?

Author

Penelope Garrood; Kieren G. Hollingsworth; Michelle Eagle; Benjamin S. Aribisala; Daniel Birchall; Kate Bushby; Volker Straub

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

2009

Language

EN

Field

Medicine (Health Sciences)