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Hesperidin, an Antioxidant Flavonoid, Prevents Acrylonitrile-induced Oxidative Stress in Rat Brain by El-Sayed M. El-Sayed; Osama M. Abo-Salem; Mohamed F. Abd-Ellah; Gamil M. Abd-Alla is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Hesperidin, an Antioxidant Flavonoid, Prevents Acrylonitrile-induced Oxidative Stress in Rat Brain about?
## Abstract Acrylonitrile (ACN) is a volatile, toxic liquid used as a monomer in the manufacture of synthetic rubber, styrene plastics, acrylic fiber, and adhesives. ACN is a potent neurotoxin. A role for free radical mediated lipid peroxidation in the toxicity of ACN has been suggested. We examined the ability of hesperidin, an antioxidant flavonoid, to attenuate ACN‐induced alterations in lipid peroxidation in rat brains. The daily oral administration of ACN to male albino rats in a dose of 50 mg/kg bwt for a period of 28 days produced a significant elevation in brain lipid peroxides measured as malondialdehyde (MDA) amounting to 107%, accompanied by a marked decrease in brain‐reduced glutathione (GSH) content reaching 63%. In addition, ACN administration resulted in significant reductions in the enzymatic antioxidant parameters of brain; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH‐Px), and glutathione‐__S__‐transferase (GST) recording 43%, 64%, 52%, and 43%, respectively. On the other hand, pretreatment with hesperidin and its coadministration with ACN once daily in a dose of 200 mg/kg bwt i.p. for 28 days ameliorated ACN‐induced alterations in brain
Who reads Hesperidin, an Antioxidant Flavonoid, Prevents Acrylonitrile-induced Oxidative Stress in Rat Brain?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- El-Sayed M. El-Sayed; Osama M. Abo-Salem; Mohamed F. Abd-Ellah; Gamil M. Abd-Alla
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1095-6670)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)