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Investigation on the Co-extrudability and Spheronization Properties of Wet Masses by J.F Pinto; M.H Lameiro; P Martins is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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In the present work, preliminary results of co-extrusion and spheronization of wet masses are reported. A ram co-extruder, manufactured in-house, was designed with two concentric single dies mounted on two concentric and independent chambers. This equipment has allowed the production of three types of extrudates (rod or solid extrudates, tubular or hollow extrudates and co-extrudates). Different wet mixtures of microcrystalline cellulose, lactose, a non-soluble in water dye and water were produced and used to feed the chambers of the ram co-extruder. Extrusions of the wet masses were carried out at different speeds of the ram (25-400 mm/min). The extrudates were evaluated according to surface characteristics (by visual inspection), force of extrusion and duration of steady-state (after recording the force applied to the ram and its displacement). Simultaneously, for each process of extrusion it was possible to assess the angles of convergence to the bottom of the chambers for both the external and internal chambers. These angles reflected the high complexity of the extrusion occurring on the external chamber in consequence of its annular geometry, in which the bisecting-line was no

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Author

J.F Pinto; M.H Lameiro; P Martins

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2001

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)