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Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients by Thomas L. Perry; Voon Wee Yong is a Neuroscience article available to read on EtoBox.

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Glutathione transferase activity and total glutathione (GSH) content were measured in several regions of autopsied brain from patients dying with idiopathic Parkinson's disease (PD) or progressive supranuclear palsy (PSP), and from control subjects. A significant deficiency of GSH was found in the substantia nigra, but not in 5 other brain regions of PD patients, nor in PSP patients' brains. Glutathione transferase activity was similar in the substantia nigra of PD, PSP and control patients. Since total GSH is consumed only by conjugation in detoxification processes, nigral GSH deficiency in PD patients implies continued local presence of a possible causative neurotoxin up to the time of death. Idiopathic Parkinson's disease (PD) affects about 200 of every 100,000 persons [6] and symptoms appear when approximately 80% of dopaminergic nigrostriatal neurons have been lost [l]. The disorder is infrequently genetically determined [17], and Calne and Langston [2] have suggested that PD may be caused by damage to dopaminergic nigrostriatal neurons by one or more unidentified environmental toxins. About 45 of patients who manifest parkinsonian symptoms suffer instead from a different diso

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Author

Thomas L. Perry; Voon Wee Yong

Published

1986

Language

EN

Field

Neuroscience (Life Sciences)