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Effects of H~1~ antihistamines on adhesion molecules: a possible rationale for long‐term treatment by G. Ciprandi; G. Passalacqua; G. W. Canonica is a Medicine article available to read on EtoBox.
What is Effects of H~1~ antihistamines on adhesion molecules: a possible rationale for long‐term treatment about?
Our knowledge of the mechanisms underlying the allergic reaction has increased rapidly and has revealed a complex network of cells, mediators and cytokines. The intercellular adhesion system (and the ICAM‐1 molecule in particular) appeared to play a pivotal role in the accumulation of inflammatory cells at the site of allergic reaction. The new antihistamines have been demonstrated to be capable of affecting several phenomena of the allergic inflammation, including mediator release, cellular activation and adhesion molecule expression. Taking into consideration the central role of adhesion molecules, the modulation of their expression may represent an important therapeutic target. The nasal and the conjunctival challenges represent two useful models for the __in vivo__ study of the antiallergic activity of drugs, as they allow investigation of a wide variety of parameters: inflammatory infiltrate, ICAM‐1 expression, concentration of soluble mediators.
Who reads Effects of H~1~ antihistamines on adhesion molecules: a possible rationale for long‐term treatment?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- G. Ciprandi; G. Passalacqua; G. W. Canonica
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-7894)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)