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Feasibility of Longitudinal Brain PET with Real-Time Arterial Input Function in Rats by David Rey-Bretal; Alexis Moscoso; Noemí Gómez-Lado; Anxo Fernández-Ferreiro; Jesús Silva-Rodríguez; Álvaro Ruibal; Pablo Aguiar is a Medicine article available to read on EtoBox.

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## Purpose: Preclinical dynamic brain pet studies remain hampered by the limitations related to the measurement of the arterial input function (aif). in this regard, the use of an arterial-venous shunt is a promising method for the generation of real-time aifs, but its application in longitudinal studies is still impeded by the cumbersome surgeries and high failure rates. we studied the feasibility and reproducibility of double arterial-venous shunt strategies for conducting longitudinal pet studies with real-time aifs in rats. ## Procedures: We studied the feasibility of double arterial-venous shunts in rats in the right/left inguinal region and evaluated inter-animal and intra-animal aif reproducibilities. image-derived input function (idif) was also obtained for comparison. dynamic brain fdg pet studies were conducted to estimate kinetic constants and cerebral metabolic rate of glucose (cmr) obtained from standard 2-tissue compartment (2tcm) and patlak analysis. ## Results: We showed that longitudinal aifs from double arterial-venous shunts can be obtained with very high success rate of the surgeries (88 %). our results provided highly reproducible aif measurements with low inte

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Author

David Rey-Bretal; Alexis Moscoso; Noemí Gómez-Lado; Anxo Fernández-Ferreiro; Jesús Silva-Rodríguez; Álvaro Ruibal; Pablo Aguiar

Publisher

Springer-Verlag; Springer New York LLC; Elsevier BV; Springer Science and Business Media LLC (ISSN 1536-1632)

Published

2020

Language

EN

Field

Medicine (Health Sciences)