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Translation of both 5′TOP and non-TOP host mRNAs continues into the late phase of Baculovirus infection by M. M. Van Oers; M. Doitsidou; A. A. M. Thomas; R. A. De Maagd; J. M. Vlak is a Agricultural and Biological Sciences article available to read on EtoBox.

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## Abstract Complete cDNA sequences were obtained for ribosomal protein (rp) L15 and eukaryotic initiation factor eIF2α from the lepidopteran insect __Spodoptera frugiperda__, and for elongation factor eEF2 from __S. exigua.__ The presence of a 5′ terminal oligopyrimidine (TOP) tract classified the lepidopteran rpL15 transcript as a TOP mRNA. For eEF2, two types of transcripts were observed, one of which had a 5′TOP tract. The transcript levels for rpL15__,__ eEF2 and eIF2α decreased following baculovirus infection. Polysome analysis showed that the corresponding mRNAs remained to be translated until at least 16 h post‐infection for both TOP and non‐TOP mRNAs. Baculovirus‐induced host shut‐off therefore appears to be regulated at the level of RNA abundance rather than at the translational level.

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Author

M. M. Van Oers; M. Doitsidou; A. A. M. Thomas; R. A. De Maagd; J. M. Vlak

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0962-1075)

Published

2003

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)