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Comparison of Biological Effectiveness of Carbon-Ion Beams in Japan and Germany by Akiko Uzawa; Koichi Ando; Sachiko Koike; Yoshiya Furusawa; Yoshitaka Matsumoto; Nobuhiko Takai; Ryoichi Hirayama; Masahiko Watanabe; Michael Scholz; Thilo Elsässer; Peter Peschke is a Medicine article available to read on EtoBox.
What is Comparison of Biological Effectiveness of Carbon-Ion Beams in Japan and Germany about?
Purpose: To compare the biological effectiveness of 290 MeV/amu carbon-ion beams in Chiba, Japan and in Darmstadt, Germany, given that different methods for beam delivery are used for each. Methods and Materials: Murine small intestine and human salivary gland tumor (HSG) cells exponentially growing in vitro were irradiated with 6-cm width of spread-out Bragg peaks (SOBPs) adjusted to achieve nearly identical beam depth-dose profiles at the Heavy-Ion Medical Accelerator in Chiba, and the SchwerIonen Synchrotron in Darmstadt. Cell kill efficiencies of carbon ions were measured by colony formation for HSG cells and jejunum crypts survival in mice. Cobalt-60 g rays were used as the reference radiation. Isoeffective doses at given survivals were used for relative biological effectiveness (RBE) calculations and interinstitutional comparisons. Results: Isoeffective D 10 doses (mean ± standard deviation) of HSG cells ranged from 2.37 ± 0.14 Gy to 3.47 ± 0.19 Gy for Chiba and from 2.31 ± 0.11 Gy to 3.66 ± 0.17 Gy for Darmstadt. Isoeffective D 10 doses of gut crypts after single doses ranged from 8.25 ± 0.17 Gy to 10.32 ± 0.14 Gy for Chiba and from 8.27 ± 0.10 Gy to 10.27 ± 0.27 Gy for Darm
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- Author
- Akiko Uzawa; Koichi Ando; Sachiko Koike; Yoshiya Furusawa; Yoshitaka Matsumoto; Nobuhiko Takai; Ryoichi Hirayama; Masahiko Watanabe; Michael Scholz; Thilo Elsässer; Peter Peschke
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)