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The document discusses the use of covalent warheads targeting cysteine residues in drug design, highlighting the advantages of irreversible and reversible covalent ligands for improved selectivity and prolonged pharmacological action. It details various chemical strategies, including α,β-unsaturated carbonyls and nucleophilic aromatic substitutions, to enhance reactivity and minimize off-target effects. The text also emphasizes the importance of balancing reactivity profiles and the role of sterics and elec

Author

b99b02055

Language

EN