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CD41+ and CD42+ hematopoietic progenitor cells may predict platelet engraftment after allogeneic peripheral blood stem cell transplantation by T. Demirer; O. Ilhan; M. Arat; Y. Genç; M. Özcan; K. Dalva; H. Çelebi; M. Beksaç; H. Akan; G. Gürman; N. Konuk; A. Uysal; Ö. Arslan; H. Koç is a Medicine article available to read on EtoBox.
What is CD41+ and CD42+ hematopoietic progenitor cells may predict platelet engraftment after allogeneic peripheral blood stem cell transplantation about?
## Abstract The objective of this study was to quantify subpopulations of CD34+ cells such as CD41+ and CD42+ cells that might represent megakaryocyte (MK) precursors in peripheral blood stem cell (PBSC) collections of normal, recombinant human granulocyte‐colony stimulating factor (rhG‐CSF) primed donors and to determine whether there is a statistical association between the dose infused megakaryocytic precursors and the time course of the platelet recovery following an allogeneic PBSC transplantation. Twenty‐six patients with various hematologic malignancies transplanted from their HLA identical siblings between July 1997 and December 1999 were used. All patients except one with severe aplastic anemia who had cyclophosphamide (CY) alone received busulfan‐CY as preparative regimen and cyclosporine‐methotrexate for GVHD prophylaxis. Normal healthy donors were given rhG‐CSF 10 μg/kg/day subcutaneously twice daily and PBSCs were collected on days 5 and 6. The median number of infused CD34+, CD41+ and CD42+ cells were 6.61 × 10^6^/kg (range 1.47–21.41), 54.85 × 10^4^/kg (5.38–204.19), and 49.86 × 10^4^/kg (6.82–430.10), respectively. Median days of ANC 0.5 × 10^9^/L and platelet 20 ×
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- Author
- T. Demirer; O. Ilhan; M. Arat; Y. Genç; M. Özcan; K. Dalva; H. Çelebi; M. Beksaç; H. Akan; G. Gürman; N. Konuk; A. Uysal; Ö. Arslan; H. Koç
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0733-2459)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)