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High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains by Keenan, Brendan T; Galante, Raymond J; Lian, Jie; Simecek, Petr; Gatti, Daniel M; Zhang, Lin; Lim, Diane C; Svenson, Karen L; Churchill, Gary A; Pack, Allan I is a Psychology article available to read on EtoBox.
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## Abstract ## Study Objectives This study describes high-throughput phenotyping strategies for sleep and circadian behavior in mice, including examinations of robustness, reliability, and heritability among Diversity Outbred (DO) mice and their eight founder strains. ## Methods We performed high-throughput sleep and circadian phenotyping in male mice from the DO population (n = 338) and their eight founder strains: A/J (n = 6), C57BL/6J (n = 14), 129S1/SvlmJ (n = 6), NOD/LtJ (n = 6), NZO/H1LtJ (n = 6), CAST/EiJ (n = 8), PWK/PhJ (n = 8), and WSB/EiJ (n = 6). Using infrared beam break systems, we defined sleep as at least 40 s of continuous inactivity and quantified sleep–wake amounts and bout characteristics. We developed assays to measure sleep latency in a new environment and during a modified Murine Multiple Sleep Latency Test, and estimated circadian period from wheel-running experiments. For each trait, broad-sense heritability (proportion of variability explained by all genetic factors) was derived in founder strains, while narrow-sense heritability (proportion of variability explained by additive genetic effects) was calculated in DO mice. ## Results Phenotypes were robust t
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- Author
- Keenan, Brendan T; Galante, Raymond J; Lian, Jie; Simecek, Petr; Gatti, Daniel M; Zhang, Lin; Lim, Diane C; Svenson, Karen L; Churchill, Gary A; Pack, Allan I
- Publisher
- Associated Professional Sleep Societies, LLC; Oxford University Press; Oxford University Press (OUP) (ISSN 0161-8105)
- Published
- 2020
- Language
- EN
- Field
- Psychology (Health Sciences)