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Mechanisms underlying the beneficial effects of Kaiyu Granule for depression by Xi Jin; Yidan Zhang; Qiaoying Li; Jianjun Zhao is a Neuroscience article available to read on EtoBox.

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The proprietary Chinese medicine preparation __Kaiyu__ Granule is made of __bupleurum, nutgrass galingale rhizome, szechwan lovage rhizome, turmeric root tuber, white peony alba, cape jasmine fruit, fried semen ziziphi jujubae__, and __prepared liquorice root__. It is a common recipe for the clinical treatment of depression in China. In this study, after 21 days of unpredictable stress exposure, Wistar rats exhibited similar behavioral changes to patients with depression. Moreover, G-protein-coupled inwardly rectifying K^+^ channel 1 mRNA and protein expression were significantly reduced in rat hippocampal CA1 and CA3 regions. However, G-protein-coupled inwardly rectifying K^+^ channel 1 mRNA, protein expression, and rat behavior were clearly better after administration of 12, 8, or 4 g/kg of __Kaiyu__ Granule when depression model rats underwent stress. 12 g/kg of __Kaiyu__ Granule had the most obvious effects on the increased expression of G-protein-coupled inwardly rectifying K^+^ channel 1 mRNA and protein in rat hippocampal CA1 and CA3 regions. These results suggested that __Kaiyu__ Granule improved depression by affecting G-protein-coupled inwardly rectifying K^+^ channel 1 e

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Author

Xi Jin; Yidan Zhang; Qiaoying Li; Jianjun Zhao

Published

2014

Language

EN

Field

Neuroscience (Life Sciences)