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What is Abnormal IGF Regulation in Pathophysiology about?
This review discusses the role of the growth hormone (GH)/insulin-like growth factor (IGF) axis in human growth and its implications in various pathophysiological conditions. It highlights recent findings on mutations in the protease pregnancy-associated plasma protein-A2 (PAPP-A2), which affect IGF-1 regulation and contribute to growth disorders. The document emphasizes the complexity of IGF signaling and its potential as a therapeutic target for related diseases.
- Author
- ecsnebula
- Language
- EN