Can I read TGF-β signaling, Smads, and tumor suppressors on EtoBox?

TGF-β signaling, Smads, and tumor suppressors by Richard W. Padgett; Pradeep Das; Srikant Krishna is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is TGF-β signaling, Smads, and tumor suppressors about?

The transforming growth factor-␤ (TGF-␤) superfamily is used throughout animal development for regulating the growth and patterning of many tissue types. During the past few years, rapid progress has been made in deciphering how TGF-␤ signals are transduced from outside the cell to the nucleus. This progress is based on biochemical studies in vertebrate systems and a combination of genetic studies in Drosophila and Caenorhabditis elegans. These studies have identified a novel family of signaling proteins, the Smad family. Smads can act positively and be phosphorylated by TGF-␤-like receptors or can act negatively and prevent activation of the positively acting group. The positively acting Smads translocate to the nucleus, bind DNA, and act as transcriptional activators. Thus, genetic and biochemical studies suggest a very simple signaling pathway, in which Smads are the primary downstream participant.

Who reads TGF-β signaling, Smads, and tumor suppressors?

Author

Richard W. Padgett; Pradeep Das; Srikant Krishna

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0265-9247)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)