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Ultra-high-resolution Ion Mobility Spectrometry—current Instrumentation, Limitations, and Future Developments by Ansgar T. Kirk; Alexander Bohnhorst; Christian-Robert Raddatz; Maria Allers; Stefan Zimmermann is a Chemistry article available to read on EtoBox.

What is Ultra-high-resolution Ion Mobility Spectrometry—current Instrumentation, Limitations, and Future Developments about?

With recent advances in ionization sources and instrumentation, ion mobility spectrometers (IMS) have transformed from a detector for chemical warfare agents and explosives to a widely used tool in analytical and bioanalytical applications. This increasing measurement task complexity requires higher and higher analytical performance and especially ultra-high resolution. In this review, we will discuss the currently used ion mobility spectrometers able to reach such ultra-high resolution, defined here as a resolving power greater than 200. These instruments are drift tube IMS, traveling wave IMS, trapped IMS, and field asymmetric or differential IMS. The basic operating principles and the resulting effects of experimental parameters on resolving power are explained and compared between the different instruments. This allows understanding the current limitations of resolving power and how ion mobility spectrometers may progress in the future. Graphical abstract.

Who reads Ultra-high-resolution Ion Mobility Spectrometry—current Instrumentation, Limitations, and Future Developments?

Author

Ansgar T. Kirk; Alexander Bohnhorst; Christian-Robert Raddatz; Maria Allers; Stefan Zimmermann

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Springer Nature (ISSN 1618-2650)

Published

2019

Language

EN

Field

Chemistry (Physical Sciences)