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Brain-derived Neurotrophic Factor Signaling in the Neuromuscular Junction During Developmental Axonal Competition and Synapse Elimination by Josep Tomàs; Víctor Cilleros-Mañé; Laia Just-Borràs; Marta Balanyà-Segura; Aleksandra Polishchuk; Laura Nadal; Marta Tomàs; Carolina Silvera-Simón; Manel M. Santafé; Maria A. Lanuza is a Neuroscience article available to read on EtoBox.

What is Brain-derived Neurotrophic Factor Signaling in the Neuromuscular Junction During Developmental Axonal Competition and Synapse Elimination about?

## Abstract During the development of the nervous system, there is an overproduction of neurons and synapses. Hebbian competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or strengthening. We have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway, at the neuromuscular junction, in the axonal development and synapse elimination process __versus__ the synapse consolidation. The purpose of this review is to describe the neurotrophic influence on developmental synapse elimination, in relation to other molecular pathways that we and others have found to regulate this process. In particular, we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors, coupled to downstream serine-threonine protein kinases A and C (PKA and PKC) and voltage-gated calcium channels, at different nerve endings in developmental competition. The dynamic changes that occur simultaneously in several nerve terminals and synapses

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Author

Josep Tomàs; Víctor Cilleros-Mañé; Laia Just-Borràs; Marta Balanyà-Segura; Aleksandra Polishchuk; Laura Nadal; Marta Tomàs; Carolina Silvera-Simón; Manel M. Santafé; Maria A. Lanuza

Publisher

Medknow

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)