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Regeneration restores some of the altered electrical properties of axotomized bullfrog B-cells by M. E. M. Kelly; M. A. Bisby; Ken Lukowiak is a Neuroscience article available to read on EtoBox.

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In bullfrog B-type sympathetic neurones axon injury produces substantial changes in soma1 membrane properties. These include a shortening of action potential afterhyperpolarization (AHP) and an increase in action potential (AP) duration. In the present experiments we compared two injury situations: nerve crush, which was followed by regeneration, and nerve cut, after which regeneration to the original target was prevented, to investigate whether these electrophysiological changes were related to axon regeneration. Both crush and cut injuries produced a similar maximum decrease in AHP duration (to 33 and 30%) by 14 days after axotomy. After nerve crush, AHP duration recovered to within control values by 42 days, while after cut it remained depressed. AHP amplitude decreased to the same extent after nerve crush or cut (to 62 and 58%), but the rate of decrease was slower following crush when compared with cut, and following both types of injury it still remained depressed at 42 and 49 days. Changes in AP duration also took longer to occur following nerve crush, reaching maximal values at 35-42 days, at which time AHP duration had returned to within the normal range. The early reductio

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Author

M. E. M. Kelly; M. A. Bisby; Ken Lukowiak

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3034)

Published

1988

Language

EN

Field

Neuroscience (Life Sciences)