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CEP55, serving as a diagnostic marker gene for osteosarcoma, triggers the JAK2-STAT3-MMPs axis by Yiqun Yan; Junyan He; Wendan Cheng is a Medicine article available to read on EtoBox.
What is CEP55, serving as a diagnostic marker gene for osteosarcoma, triggers the JAK2-STAT3-MMPs axis about?
## Background: Osteosarcoma (OS) stands as the prevailing form of primary bone cancer in clinical practice. Lack of effective treatment options and an overall poor prognosis are caused by the disease’s exceptionally rare occurrence and unclear rationale. ## Objective: This study’s goal is to determine diagnostic marker genes involved in the progression of OS and investigate related pathways and mechanisms with the purpose of offering effective methods for OS diagnostics and therapy. ## Methods: The Gene Expression Omnibus database provided the gene microarray data. Core genes were identified through differential expression analysis and WGCNA. Three techniques for machine learning, random forest, least absolute shrinkage and selection operator regression, and support vector machine recursive feature elimination, were used to further screen the core genes and obtain diagnostic marker genes for OS. The specificity and sensitivity of the diagnostic marker genes for OS diagnosis were evaluated using receiver operating characteristic curves. Western blotting analysis was used for preliminary validation of the diagnostic marker genes and their related pathways. ## Results: Two diagnostic
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- Author
- Yiqun Yan; Junyan He; Wendan Cheng
- Publisher
- Lippincott Williams & Wilkins
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)