Can I read COVID-19-associated liver injury: from bedside to bench on EtoBox?

COVID-19-associated liver injury: from bedside to bench by Dongxiao Li; Xiangming Ding; Meng Xie; Dean Tian; Limin Xia is a Medicine article available to read on EtoBox.

What is COVID-19-associated liver injury: from bedside to bench about?

The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a global challenge since December 2019. Although most patients with COVID-19 exhibit mild clinical manifestations, in approximately 5% of these patients, the disease eventually progresses to severe lung injury or even multiorgan dysfunction. This situation represents various challenges to hepatology. In the context of liver injury in patients with COVID-19, several key problems need to be solved. For instance, it is important to determine whether SARS-CoV-2 can directly invade liver, especially when ACE2 appears to be negligibly expressed on hepatocytes. In addition, the mechanisms underlying liver dysfunction in COVID-19 patients are not fully understood, which are likely multifactorial and related to hyperinflammation, dysregulated immune responses, abnormal coagulation and drugs. Here, we systematically describe the potential pathogenesis of COVID-19-associated liver injury and propose several hypotheses about its etiopathogenesis.

Who reads COVID-19-associated liver injury: from bedside to bench?

Author

Dongxiao Li; Xiangming Ding; Meng Xie; Dean Tian; Limin Xia

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)