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Chest X-ray interpretation does not complement Xpert MTB/RIF in diagnosis of smear-negative pulmonary tuberculosis among TB-HIV co-infected adults in a resource-limited setting by Nakiyingi, Lydia (author);Bwanika, John Mark (author);Ssengooba, Willy (author);Mubiru, Frank (author);Nakanjako, Damalie (author);Joloba, Moses L. (author);Mayanja-Kizza, Harriet (author);Manabe, Yukari C. (author) is a Medicine article available to read on EtoBox.

What is Chest X-ray interpretation does not complement Xpert MTB/RIF in diagnosis of smear-negative pulmonary tuberculosis among TB-HIV co-infected adults in a resource-limited setting about?

## Abstract ## Background Chest X-ray (CXR) interpretation remains a central component of the current World Health Organization recommendations as an adjuvant test in diagnosis of smear-negative tuberculosis (TB). With its low specificity, high maintenance and operational costs, utility of CXR in diagnosis of smear-negative TB in high HIV/TB burden settings in the Xpert MTB/RIF era remains unpredictable. We evaluated accuracy and additive value of CXR to Xpert MTB/RIF in the diagnosis of TB among HIV-positive smear-negative presumptive TB patients. ## Methods HIV co-infected presumptive TB patients were recruited from the Infectious Diseases Institute outpatient clinic and in-patient medical wards of Mulago Hospital, Uganda. CXR films were reviewed by two independent radiologists using a standardized evaluation form. CXR interpretation with regard to TB was either positive (consistent with TB) or negative (normal or unlikely TB). Sensitivity, specificity and predictive values of CXR and CXR combined with Xpert MTB/RIF for diagnosis of smear-negative TB in HIV-positive patients were calculated using sputum and/or blood mycobacterial culture as reference standard. ## Results Three hu

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Author

Nakiyingi, Lydia (author);Bwanika, John Mark (author);Ssengooba, Willy (author);Mubiru, Frank (author);Nakanjako, Damalie (author);Joloba, Moses L. (author);Mayanja-Kizza, Harriet (author);Manabe, Yukari C. (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)