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This document describes research into developing a gastroretentive drug delivery system for the anti-ulcer drug lansoprazole using hydroxypropylmethylcellulose (HPMC) polymers. Floating matrix tablets were prepared using wet granulation with HPMC K4M and HPMC K15M polymers. The tablets were evaluated for characteristics such as hardness, thickness, friability, drug content and in vitro drug release over 24 hours. Tablets showed controlled and prolonged drug release. The best formulation was tested in vivo u

Author

Siti Rositah

Language

EN